Theoretical and Experimental Biophysics
Professor Zhou joined UIC in 2017, after faculty appointments at Hong Kong University of Science and Technology, Drexel University, and Florida State University. He has served on many grant review panels and journal editorial boards. His group conducts theoretical, computational, and experimental studies on the structure, dynamics, and function of proteins. Areas of special interest include: (1) binding kinetics and allostery of structured and disordered proteins; (2) crowding and emergent properties in cellular environments; (3) structure and function of ion channels and other membrane proteins; and (4) structures and mechanisms of peptide self-assembly. This research is supported by multiple grants from the National Institutes of Health.
M. Sharma, M. Yi, H. Dong, H. Qin, E. Peterson, D. D. Busath, H.-X. Zhou, and T. A. Cross (2010). Insight into the mechanism of the influenza A proton channel from a structure in a lipid bilayer. Science 330, 509-512.
S. Qin and H.-X. Zhou (2017). Protein folding, binding, and droplet formation in cell-like conditions. Curr. Opin. Struct. Biol. 43, 28-37.
X. Pang and H.-X. Zhou (2017). Rate constants and mechanisms of protein-ligand binding. Annu. Rev. Biophys. 46,105-130.
H.-X. Zhou (2017). Gating motions and stationary gating properties of ionotropic glutamate receptors: computation meets electrophysiology. Acc. Chem. Res. 50, 814-822.
L. Ou, M. Matthews, X. Pang, and H.-X. Zhou (2017). The dock-and-coalesce mechanism for the association of a WASP disordered region with the Cdc42 GTPase. FEBS. J. 284, 3381-3391.