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Photo of Zhou, Huan-Xiang

Huan-Xiang Zhou, PhD

Professor and LAS Distinguished Chair in the Natural Sciences



Building & Room:

3462 SES


845 West Taylor St.

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Professor Zhou joined UIC in 2017, after faculty appointments at Hong Kong University of Science and Technology, Drexel University, and Florida State University. He has served on many grant review panels and journal editorial boards. His group conducts theoretical, computational, and experimental studies on the structure, dynamics, and function of proteins. Areas of special interest include: (1) kinetics and mechanisms of protein association; (2) crowding and emergent properties in cellular environments; (3) structure and function of ion channels and other membrane proteins; and (4) structures and mechanisms of peptide self-assembly. This research is supported by multiple grants from the National Institutes of Health.

Selected Publications

  • M. Sharma, M. Yi, H. Dong, H. Qin, E. Peterson, D. D. Busath, H.-X. Zhou, and T. A. Cross (2010). Insight into the mechanism of the influenza A proton channel from a structure in a lipid bilayer. Science 330, 509-512.
  • S. Qin and H.-X. Zhou (2017). Protein folding, binding, and droplet formation in cell-like conditions. Curr. Opin. Struct. Biol. 43, 28-37.
  • X. Pang and H.-X. Zhou (2017). Rate constants and mechanisms of protein-ligand binding. Annu. Rev. Biophys. 46,105-130.
  • H.-X. Zhou (2017). Gating motions and stationary gating properties of ionotropic glutamate receptors: computation meets electrophysiology. Acc. Chem. Res. 50, 814-822.
  • L. Ou, M. Matthews, X. Pang, and H.-X. Zhou (2017). The dock-and-coalesce mechanism for the association of a WASP disordered region with the Cdc42 GTPase. FEBS. J. 284, 3381-3391.


PhD (1988), Drexel University