Investigations of Living Cells Adhesion with Neutron Surface Scattering
The presentation will discuss utilization of neutron surface scattering methods (reflectivity and off-specular) to study adhesion of living cells and their response to external mechanical forces simulating the blood flow. Understanding structure and functionality of bio-interfaces is important for broad range of applications: from creation of innovative functionalized biomimetic materials to addressing functions of complex biological systems.
Due to non-perturbative nature, isotopic sensitivity and penetrability neutrons are well suited to obtain length-scale and density information about well-ordered, homogenous layered materials, such as model
phospholipid mono- and bi-layers and variety of soft-condensed thin films.
It is more challenging to obtain reliable information about complex, poorly stratified and inherently inhomogeneous samples like living cells. However, understanding cell adhesion can result in mitigating pathologies like atherosclerosis and understanding of migration of cancerous cells.
Cm-Bio 11-21 Majewski flyer