Wednesday Colloquium: Prof. Dave Thirumalai, University of Texas, Austin.  Add To Calendar

  • Date(s): Wednesday, 9/21 3:00 PM to Wednesday, 9/21 4:00 PM
  • Speaker: Prof. Dave Thirumalai
  • Host: Anjum Ansari & Ursula Perez-Salas
  • Campus Address: 138 SES (Science & Engineering South)

Title: Design principles governing the motility of myosin motors

Abstract: Myosin V, two-headed motor protein and a member of the myosin super family, ferries cellular cargo by walking hand-over-hand on actin filaments.  Interplay between ATP-driven conformational changes in the motor head and stress due to load produces a variety of stepping dynamics: the motor can step forward or backward, or "stomp", where one of the heads detaches and rebinds to the same site. I will present theory that captures all these behaviors, quantitatively matching a wide array of single molecule experiments.  The theory lays out the structural and chemical design principles underlying the motor's robust function, which provides a guide for how bioengineering might alter its dynamics [1]. The theoretical results will be complemented with simulations describing the role the internal dynamics of the motor domain plays in motility [2].
 Colloq flyer 9-21