Title: Ganglioside GM1 in ternary membranes: in vitro and in silico studies
Abstract: Gangliosides are the sialic acid containing glycosphingolipids that are particularly abundant in neuronal membranes, particularly at the synapses. They have been implicated to have diverse functional and modulating roles. The mono-sialylated ganglioside, GM1, in membrane serves as natural receptor of numerous virus and toxins, regulates the nerve regeneration, growth, and are involved in several neuro-degenerative diseases like, Alzheimer’s disease, Hungtinton’s disease, Parkinson’s disease. In addition to their functional roles, they are known to be major regulators of membrane dynamics. They are known to form cross-linking and microdomains and are important components of lipid rafts. It has been shown that presence of ganglioside in model ternary membranes can affect the dynamics of phospholipids. For last several years we have been using both experiments and simulations to understand the structural and functional roles of GM1. A brief overview of the results will be presented.
Cm-Bio 12-3 Mukhopadhyay