Departmental Colloquium: Dr. Khalili-Araghi  Add To Calendar

  • Date(s): Tuesday, 4/24 12:30 PM to Tuesday, 4/24 1:30 PM
  • Speaker: Dr. Khalili-Araghi
  • Host:
  • Campus Address: 2214 SES Science and Engineering South
  • Email: aburgo3@uic.edu
Voltage-gated potassium channels are membrane proteins that are responsible for maintaining the electrostatic potential across the cell membrane. These channels respond to changes in membrane potential and open to allow passage of their namesake ions across the membrane. In neurons and other excitable cells, voltage-gated cation channels generate electrical signals that are then propagated along the length of the nerve cell. Using molecular dynamics simulations, we have developed atomic models of the channel in the open and closed state that are in broad agreement with experimental results obtained through various techniques. To investigate the gating mechanism, a theoretical framework is developed to calculate the coupling between membrane potential and structural changes in the protein. These results directly correlate with experimentally measured gating charges in cation channels, and other voltage-sensitive proteins. At the end, I will review our recent advances on the NaK-ATPase, another voltage sensitive membrane protein