Departmental Colloquium: Enrique De La Cruz  Add To Calendar

  • Date(s): Wednesday, 10/26 3:00 PM to Wednesday, 10/26 5:00 PM
  • Speaker: Professor Enrique M. De La Cruz, Department of Molecular Biophysics and Biochemistry at Yale University
  • Host:
  • Campus Address: 238 SES Science and Engineering South
  • Email: jschwa21@uic.edu
Title: "How cofilin severs an actin filament"
Abstract: The actin regulatory protein, cofilin, promotes actin assembly dynamics by severing filaments and increasing the number of ends from which subunits add and dissociate. I will present results from biochemical and biophysical solution studies that yield a thermodynamic, kinetic, structural and mechanical description of cooperative cofilactin binding and actin filament severing. The experimental data are well described by a model in which discontinuities in filament topology, and mechanics generate stress accumulation and promote fracture preferentially at junctions of bare and cofilin-decorated segments along filaments. Computational modeling and simulations indicate an intrinsic coupling between filament bending and twisting elasticity is critical for stress accumulation.
Refreshments will be served at 2:30pm in SES 2620, High Bay Conference Room